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Prolonged use of Fosamax, also referred to by the generic name bisphosphonate alendronate, may increase the risk of fractures of the femur, the large thigh bone that connects the leg to the hip, according to physicians at the Weill Medical College of Cornell University.
There has been a build-up of evidence suggesting that long-term alendronate use may overly suppress bone metabolism, limiting the repair of microdamage and increasing the risk of fractures, Dr. Joseph M. Lane and colleagues report in the Journal of Orthopaedic Trauma.
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