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Dr. Eric Li's Blog
In the new book, Testosterone for Life, Harvard Doctor, Abraham Morgentaler, wrote about the myth of testosterone replacement and prostate cancer. It is a landmark book detailing the history of scientific discovery and the implication to male hormone replacement. Below is a summary of my reading of the book:
Early in this century, Dr. Charles Huggins' Nobel prize winning experiments showed that castration or injection of estrogen can cure or prevent prostate cancer. Since that time, the standard education of medicine has been that testosterone is bad for the prostate. Therefore, male hormone replacement therapy can be risky.
After over 65 years, recently, new scientific discover has shown just the opposite: 1. Low blood levels of testosterone do not protect against prostate cancer, and actually may increase the risk. 2. High testosterone level do not increase the risk of prostate cancer. 3. HRT does not increase the risk even among men who are already at high risk of prostate cancer. 4. For men who have prostate cancer, and are given drugs to drop their testosterone level to near zero, administrating testosterone might increase the risk of residual cancer to start to grow.
The reason to completely overturn the old Nobel prize winning theory is due to the incomplete statistical significance of the original experiments, thus drawing the wrong conclusion.
One very important concept, uniquely to YBM Hormone protocol, still ignored by most physicians and hormone doctors, including Dr. Morgentaler's analysis, is that hormone levels are very individual dependent. Good statistics can give good generalized results. However, when giving hormone replacement therapy to an individual, it's a totally different matter.
Take for example, the medical lab reference of testosterone normal range is 260-1000 ng/dL. Is a person who have 390 ng/dL low T? Not necessarily. Some people has 390 level even when they are in their early 20's, sexual, healthy, and manly. If this is the case, suplementing testosterone way beyond his own "normal" is dangerously breaking his own hormonal balance.
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The relationship between
The relationship between testosterone levels and prostate cancer is confusing. Some studies have shown that low levels of testosterone are associated with an increased incidence of prostate cancer.
HRT does not increase the risk even among men who are already at high risk of prostate cancer.
The reason to completely overturn the old Nobel prize winning theory is due to the incomplete statistical significance of the original experiments, thus drawing the wrong conclusion.
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apanese researchers have reported that a preoperative low testosterone level is associated with a higher PSA failure rate after radical prostatectomy for localized prostate cancer compared with a normal testosterone level. The details of this study appeared in the September, 2007 issue of European Urology.
The relationship between testosterone levels and prostate cancer is confusing. Some studies have shown that low levels of testosterone are associated with an increased incidence of prostate cancer. Other studies have reported that there is no relationship between testosterone levels and the incidence of prostate cancer. However, there does not appear to be an increased risk of prostate cancer in men with normal or high levels of testosterone. The possibility that exogenous testosterone could increase the incidence of prostate cancer has been raised but not proven (see first item of related news).
The current study looked at preoperative testosterone levels in 222 men who underwent radical prostatectomy for localized prostate cancer. Forty-nine of the 222 men in this study had a testosterone levels below 300 ng/dl. In multivariate analysis, preoperative testosterone was an independent risk factor for recurrent disease (p=0.021). Patients with a low testosterone level had a five-year PSA failure-free survival of 67.8% compared with 84.9% in patients with normal testosterone levels. The other independent risk factors were Gleason score (p=0.006), surgical margin status (p=0.0001) and PSA levels (p=0.0001). These authors concluded that low preoperative testosterone levels were predictive of PSA failure after radical prostatectomy.
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Low testosterone and
Low testosterone and prostate symptoms affect nearly half of all males in the United States over the age of 50. And low testosterone and excessive urination symptoms should be understood by every man as he ages.
The most common and noticeable first sign of this health issue is related to prostate enlargement. The prostate is a walnut size gland located near the bladder. The prostate is a common area of non-cancerous tissue growth or enlargement called benign prostatic hyperplasia or BPH.
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HRT does not increase the risk even among men who are already at high risk of prostate cancer.
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For men who have prostate
For men who have prostate cancer, and are given drugs to drop their testosterone level to near zero, administrating testosterone might increase the risk of residual cancer to start to grow.
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