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由 Dr. Eric Li 于 周四, 2009-11-12 08:31 提交。
Telomeres are short bits of specialized DNA that cap the chromosomes, which tell a cell what to do. Over time, cells divide over and over to keep the body alive. But with each cell division, telomeres get shorter. When they become too short, the cell stops dividing and lapses into a state called cell senescence. Vital tissues are no longer produced, and organs start to fail.
The new study, which focused on Ashkenazi Jews, finds those who lived the longest had inherited a hyperactive version of an enzyme called telomerase that rebuilds telomeres.
"Our research was meant to answer two questions," explained said Einstein researcher Gil Atzmon in a statement. "Do people who live long lives tend to have long telomeres? And if so, could variations in their genes that code for telomerase account for their long telomeres?" "Yes" on both accounts, the scientists conclude.
The results are detailed this week in the Proceedings of the National Academy of Sciences, and a summary can be read on "LiveScience" reported by Robert Roy Britt.
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