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Metabolism of estrogens occurs mainly in liver and gastrointestinal tissues. Most of the 
metabolism and conjugation of estrogens takes place in the liver. A major pathway of estrogen metabolism is from estradiol to estrone. In turn, estrone can be metabolized further to2-hydroxyestrone or 16alfa-hydroxyestrone. Then finally 2-hydroxyestrone or 16alfa-hydroxyestrone convert into estriol, which are then conjugated primarily as glucuronides, sulfates and thioether to readily excrete via bile, feces and urine.
Progesterone is another vitally important female hormone, which plays a critical role in a woman's body such as pregnancy, bone regeneration.
Female hormones change in magnitude and ratio during the day, the month, age, and during pregnancy.
As man ages, one of the first sign is an increase of estrogen and an increase of sex hormone binding globulin (SHBG). This, even without reduced total testosterone level, will change the key ratio/balance of testosterone/estrogen. It's a known scientific fact that this is the start of andropause - a steady process of male hormone decline and out of balance, a major cause of aging. (Read more YBM Hormone) When this happens, instead of immediately jumping into bio-identical hormone replacement therapy, a herbal approach should be first tried. This includes reducing estrogen conversion, blocking estrogen receptors, reducing DHT conversion, and stimulating testosterone production. An effective tool for reducing the estrogen effect is a high concentration extraction from cruciferous vegetables (broccoli, cauliflower, Brussels sprouts) of key ingradients, such as indole-3-carbinol (I3C), DIM (diindolymethane), ascorbigin, sulphoraphine, indoles, isothiocynates and glucosinolates. Animal studies have shown that the cruciferous vegetable extract modulates estrogen hormones by favorably changing the ratio of protective 2-hydroxyestrone versus the damaging 16-hydroxyestrone. Indole-3-carbinol also induces phase I and II detoxifying enzymes that can help neutralize estrogen metabolites and xenobiotic estrogen-like environmental chemicals. Human studies support the beneficial role of I3C in positively altering estrogen metabolism. Di-indoyl-methane (DIM), a phytonutrient found in cruciferous vegetables, has been shown in animal studies to help maintain normal levels of a potentially damaging estrogen called 4-hydroxyestrone.
- Dr. Eric Li 的blog
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Many women patients in my clinic find it beneficial taking supplements rich in phytoestrogen such as lignans. The answer is dependent on your situation. Phytoestrogen has different effect on different situations. Phytoestrogen is a weaker form of estrogen. In structure, it is similar to estradiol. But in effect, it is a lot weaker. When the body has a lot of its internal estrogen supply, an addition of phytoestrogen from foods actually make the total estrogenic effect less in the body, because it occupies some of the estrogen receptors which would otherwise occupied by the real more potent estrogen. On the other hand, if the body's own supply of estrogen is scarce, eating more phytoestrogen actually enhances the estrogenic effect of to the body. Therefore, you can see it is all dependent on your situation. For example, for a menopausal woman, phytoestrogen may enhance your estrogen in the body, while for a younger woman who has sufficient supply of estrogen, phytoestrogen may weaken the effect. Since phytoestrogen, as opposed to phytoestrogen containing whole foods, may have meaningful impact on your hormone balance, you need to make sure it's done under detailed doctor supervision.
- Dr. Ping 的blog
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I was talking to a client. He is a perfectionist in his health, fitness, and look. "I'm scared of tofu. I've stopped eating tofu," said he. "Why?" "My doctor told me it contains phytoestrogen, which can make man woman."
"Well, phytoestrogen is contained in many natural plant foods, oilseeds (such as flaxseeds, sunflower, sesame, olive, etc.), legumes (such as alfalfa, clover, peas, beans, lentils, lupins, and peanuts), grains (e.g. wheat, oats, barley, rice), fruits (e.g. berries, apples), vegetables (e.g. carrots), herbs (e.g. ginseng), alcohol (e.g. beer). Are you going to avoid all of these?" asked I.
In fact, moderate consumption of whole foods containing phytoestrogen is not only safe, but also beneficial for men. See my earlier article about tofu.
The trick is not to casually eat any phytoestrogen which is extracted artificially from foods. For example, there're products in the market for lignans extracted from flaxseeds. These man-made "natural" products become more potent or concentrated. When taking these products, it must be in conjunction with a hormone program, which
requires careful monitoring and balancing. Read more on the article on male hormone replacement, as well as YBM Hormone.
- Dr. BT 的blog
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I was listening to radio - an interview with Professor Ronald Mallett on time machines. He was talking about the amazing possibility to travel back in time. When Einstein discovered his special relativity theory, it proves that we can travel to the future, but not to the past because no speed is higher than that of light. But his theory was challenged: Suppose the sun one day were destroyed. Sunlight travels to the earth in about 12 minutes. So for 12 minutes we won't be able to know the sun has disappeared. However, the sun's gravity suddenly disappeared, so the earth would go down somewhere pretty fast. Therefore, gravity is faster than the speed of light?
Prostate cancer, like many other cancers, is definitely not fun to go through. Not only the potential of death when the cancer spread, but also the risk of side effects such as impotence after surgery. Just listen to the Voice of Prostate Cancer from the New York Times - that will motivate you to try all you can to avoid it. There's really no good "cure"! But how? One of the most significant cause of prostate cancer, like breast cancer, is hormone imbalance. As men grow older, testosterone level goes down, SHBG and thus free testosterone also goes down, making things worse. In the meantime, more testosterones are converted to DHT (a more potent form of testosterone) and estrogen - significantly changing the ratio among these hormones. To prevent hormone imbalance, first follow YBM Test to track your hormones even if you're perfectly healthy and young, then follow YBM Hormone to keep your hormones young as long as you can.
- Dr. BT 的blog
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In this article, we'll talk about male hormone replacement therapy (HRT). In the following articles, we'll cover female HRT. YBM Hormone protocol emphasize critical importance of keeping a young hormone level and balance: "The decline of sex hormones causes many degenerative diseases, among which are decreased muscle and increased fat, skin thinning, osteoporosis, depression, memory loss, decreased energy and endurance, heart diseases, prostate enlargement/cancer (male), breast cancer (female), decreased libido, impotence (male). Fundamentally, DECLINING OF SEX HORMONES MAKES ONE OLD!" There are ways to boost our hormones as the ultimate decline arrives. Except for sex chi-gong, herbal or HRT require very careful administration. This can be easily explained by the following graph, showing how hormones in male is generated (i.e., the hormone pathway). 
(curtersy to David J Handelsman MB BS, FRACP, PhD) As you can see, any products which increase testosterone (as they claim), may actually increase estradiol (a potent form of female hormone), and/or DHT (a potent form of male hormone which has been credited for prostate cancer and male pattern baldness, because testosterone can convert into these other hormones with the help of respective enzymes in the pathway. When this happens, the HRT not only does not reach the correct effect, but actually makes the hormone balance worse! Another issue is exactly at what level of testosterone, estradiol, DHT, SHBG and their relative balance does your body operate at optimal health?
To maintain a young male hormone level and balance, we need to avoid alcohol consumption. Most studies of alcohol's effects on male reproduction have been conducted in rats because the rat model mimics the human male reproductive system. Research has demonstrated that both acute and chronic alcohol exposure are associated with low levels of hypothalamic LHRH and pituitary LH in the adult and pubertal male rat, and further studies have suggested that alcohol inhibits testosterone secretion by the testes as well. For those who want to dig in a lot deeper, read this scientific paper by Loyola University researchers.
- Dr. BT 的blog
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Many of our patients visiting our anti-aging clinic are confused about tofu. This is because of the confusing report in the media. It has become a FAD that eating tofu is bad, because it "turns" male to female, "due to its phyto-estrogen content", especially when this concept is promoted by some famous doctors (e.g., watch Dr. Mercola's video). There's even articles talking about "soy makes kids gay". Is phyto-estrogen good or bad? Apparently, soy or tofu has been consumed in Japan, China, and other Asian countries for thousands of years. Why suddenly it is condemned by modern medicine and western countries? First, let me ask you if water is good?
- Dr. BT 的blog
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- Dr. Eric Li 的blog
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It's known that estrogen dominance, or sex hormone imbalance, is one of the major biomarker of aging, as well as a root cause of breast cancer in women and prostate cancer in men. It is further researched that just as the ratios between testosterone and DHT is critical in men, the ratio of 2-hydroxyestrone and 16-alpha-hydroxyestrone in both men and women is very important. 16's is much more potent than 2's. As we age, the ratio changes, causing degenerative diseases such as cancer. A good article to discuss about this is found here by New Spirit Naturals. There are saliva test to measure the ratio, and supplementation method to balance it.
- Dr. Eric Li 的blog
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Have you noticed that foods associated with lower or higher prostate cancer risk usually impact breast cancer the same way. There's plenty of scientific studies demonstrating that estrogen excess (as compared with progesterone in woman, and with testosterone in man) is the root cause of breast cancer and prostate cancer, respectively. Thus, keeping hormone balance is utmost important to staying young and vibrant. To learn more about it, go to YBM Hormone!
Estrogen is the worst enemy for men to staying young. As men age, their testosterone drops, estrogen, DHT, and SHBG go up, or at least relatively go up, causing major hormone imbalance. Grapefruits is known for increasing estradiol, the most potent component of estrogen. Here is an article about estrogen replacement. Take a note at how it talks about grapefruits.
The article about early menstrual period leading to shorter lifespan is a very important one. It confirms the philosophy of PingLongevity (see chapter 8 of Asin Longevity Secrets), as well as YBM Life (see Caloric Restriction). The fundamental secret of staying young is to let your biological clock run slow, including delaying all major biological milestones, including menstrual period, menopause, andropause, etc. The only way to do it is through caloric restriction without malnutrition. YBM Diet, plus YBM Caloric Restriction is the most nutritionally efficient diet to achieve that.
- Dr. Eric Li 的blog
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For practising Taoist Sexual Energy Cultivation, a good introduction is by Master Mantak Chia in his video (VHS) "Healing Love", and the books, "Taoist's Secrets of Love: Cultivating Male Sexual Energy," and "Healing Love through the Tao: Cultivating Female Sexual Energy."
- Master Taichi Tzu 的blog
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“这是世界最好的有关结合现代医学和古老的东方医学智慧养生之道。 ”